FOOT NOTES
No. Reference
- Data on file, Medtrade. In laboratory testing Celox was effective on
heparinized blood, blood at 56 °F blood temperature and did not
increase in temperature during use. - Tan ECTH, Bleeker CP. Field experience with a chitosan-based
hemostatic dressing. MCI Forum. 2011; 3/4-2011: 34-39. - Pozza M, Millner R. Celox (chitosan) for hemostasis in massive traumatic
bleeding: experience in Afghanistan. Eur J Emerg Med. 2011; 18: 31-33. - Observed in laboratory testing. Medtrade data on file.
- Rall J et al. Comparison of novel hemostatic dressings with QuikClot
combat gauze in a standardized swine model of uncontrolled
haemorrhage. J Trauma. 2013; 75: S150 – S156 - Littlejohn LF et al. Comparison of Celox-A, ChitoFlex, WoundStat and
Combat Gauze hemostatic agents versus standard gauze dressing in
control of hemorrhage in a swine model of penetrating trauma.
Acad Emer Med. 2011; 18: 340-350. - Kozen B et al. An Alternative Hemostatic Dressing: Comparison of
CELOX, HemCon and QuikClot. Acad Emer Med. 2008; 15:74-81. - Product instructions for use.
- Kunio N et al. Chitosan based advanced hemostatic dressing is
associated with decreased blood loss in swine uncontrolled
hemorrhage model. Am J Surg. 2013; 205:505-510. - Hoggarth A et al. Mechanism of action of a rapid-acting gauze hemostat.
Poster presentation at ATACCC 2011, Fort Lauderdale, FL. - Nancy Caroline’s Emergency Care in the Streets. Nancy Caroline.
Jones & Bartlett, Sudbury MA 2008. - DoD test results reference based on 10’ Celox™Gauze.
- CDC/NCHS, Health United States 2013, Data from National Health and
Nutritional Examination Survey. - Contains chitosan from shellfish – allergy studies show no adverse
reactions – data on file. - Johnson L et al. The in vivo assessment of an unusual new hemostat
technology.” Presented at SAWC, April 2008, San Diego. - Peng T. Biomaterials for hemorrhage control. Trends Biomat Artif
Organs. 2010; 24(1): 27-68. - Millner R, Lockhart A. Omni-stat (chitosan) arrests bleeding in
heparinised subjects in vivo: an experimental study in a model of major
peripheral vascular injury. Eur J Cardiothorac Surg 2011; 39(6):952-954. - Waibel KH et al. Safety of chitosan bandages in shellfish allergic
patients. Mil Med 2011; 176: 1153-6. - Baldrick P. The Safety of Chitosan as a pharmaceutical excipient. Regul
Toxicol Pharmacol 2010; 56(3):290-9. - Scherle C, Krol J. Can new hemostatic dressings facilitate sharp
debridement in high-risk patients? Podiatry Today 2009; 22(7):20-22. - Snyder RJ, Sigal BD. An open-label controlled clinical study of OMNI-
STAT (Chitosan) versus standard of care in post-debridement treatment
of patients with chronic wounds with or without concomitant use of
anticoagulants. Wound Care and Hyperbaric Medicine 2013; 4(2): 9-16. - Medtrade Data on File
- Eastridge B et al. Death on the battlefield (2001Y2011): Implications for
the future of combat casualty care. J Trauma 2012; 73(6): S431-S437. - Watters JM et al. Advanced hemostatic dressings are not superior to
gauze for care under fire scenarios. J Trauma 2011;70:1413-1419. - https://archive.ahrq.gov/news/newsletters/research-activities/
jan10/0110RA1.html Accessed 13 Feb. 2017 - Celox hemostatic gauze is approved by the Department of Defense for
military use. - Kauvar, D.S., Lefering, R., and Wade, C.E. Impact of hemorrhage on
trauma outcome: an overview of epidemiology, clinical presentations,
and therapeutic considerations. J Trauma. 2006;60: S3-11 - Arul GS, Bowely DM, DiRusso S. The use of Celox Gauze as an
adjunct to pelvic packing in otherwise uncontrollable pelvic
haemorrhage secondary to penetrating trauma. J R Army Med Corps
2012. 158(4): 331-334. - Quayle JM, Thomas GOR. A Pre-hospital Technique for Controlling
Haemorrhage from Traumatic Perineal and High Amputation Injuries.
JR Army Med Corps 157(4): 419-420. - Bennett BL, Littlejohn LF, Kheirabadi BS, Butler FK, Kotwal RS, Dubick
MA, Bailey JA. Management of External Hemorrhage in Tactical
Combat Casualty Care: Chitosan-Based Hemostatic Gauze Dressings,
TCCC Guidelines – Change 13-05. J Special Operations Medicine.
2014; 14(3): 12-29. - National Trauma Institute : https://www.nationaltraumainstitute.com/
home/trauma_statistics.html. Accessed 14 Feb 2017. - From Center for Disease Control and Prevention.
https://www.cdc.gov/injury/wisqars/overview/key_data.html . Accessed
14 Feb 2017. - Koksal O et l. Hemostatic effect of a chitosan linear polymer (Celox) in
a severe femoral artery bleeding rat model under hypothermia or
warfarin therapy. Turk J Trauma & Emerg Surg. 2011; 17:199-204. - Khoshmohabat H, et al. Overview of agents used for emergency
hemostasis. - Muzzi et al Successful use of a military haemostatic agent in patients
undergoing extracorporeal circulatory assistance and delayed sternal
closure. Interact Cardiovasc Thorac Surg. 2012;14(6):695-8. - Rao SB, Sharma CP. Use of chitosan as a biomaterial: studies on its
safety and hemostatic potential. J Biomed Mater Res. 1997; 34(1):21-8 - Aiba S. Studies on chitosan: 4. Lysozymic hydrolysis of partially
N-acetylated chitosans. Int J Biol Macromol 1992 vol 14, August. - UK MOD selects Celox Rapid as haemostat of choice:
https://www.celoxmedical.com/uk-mod-selects-celox-rapid/ 11 Jan 2018
TM Trademark of Medtrade Products Limited
* Combat Gauze Trademark of Z-Medica
** Chitogauze Trademark of Hemcon
*** Bolin Trademark of H&H Medical Corporation
**** Halo Trademark of Medical Devices inc